Postdoctoral Fellowships at Pfizer

1. Postdoctoral Fellow Synthetic/Biocatalysis

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locations United States - Michigan - Kalamazoo

time type Full time

job requisition id4884128

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.

What You Will Achieve

As a Postdoctoral Fellow, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be part of a Research and Development team and will be responsible for the development of technology for the production of active pharmaceutical ingredients (APIs).  You will be responsible for the synthesis of multiple custom intermediates needed to support the group's projects. This opportunity will provide industrial experience and exposure to process optimization.

 You will need to provide innovative ideas and partner with mentors to deliver gram quantities of materials in a safe and effective lab environment. Your strong foundation in general scientific practice, its principles and concepts will help in meeting critical deadlines. You will be relied on as a technical contributor to assess the assigned tasks and make decisions that involve direct application of your knowledge. It is your hard work and focus that will help in making Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It Develop the synthesis and prepare multiple key compounds to support project milestone deliverables utilizing novel chemistry.

Support Brainstorming sessions and provide input for retro synthesis options by incorporating biocatalysis/biotransformations in 2nd Generation processes.

Partner with other synthetic chemists and global EHS to support the calculation of product sustainability (NetZero 2040) metrics.

Regularly contribute and influence at the project team level.

Perform scientific laboratory studies and make recommendations to improve manufacturing reliability, cost, safety, compliance, and environmental performance.

Remain current with chemistry literature and applications of continuous development and manufacture.

Communicate appropriately on activities and progress to management, mentors, and key stakeholders.

Take personal responsibility for your own work, pushing self and others to exceed goals and deliver results.

QUALIFICATIONS

Must-Have PhD with 0-2 years of relevant experience

At least one first-author publication

Demonstrated experience in interpretation of analytical data to drive synthetic experimental plans and ability to utilize electronic tools to document information

Technical knowledge and skills in purification of biologics achieved through industrial or academic experience in research and development, technical operations, manufacturing, etc.

Knowledge of modern synthetic methodology, including aspects of asymmetric synthesis, green chemistry, catalysis, and physical organic chemistry as it relates to reaction mechanism

Strong initiative and good problem-solving skills

Good communication skills, both verbal and written

Nice-to-Have Synthetic organic chemistry laboratory experience in a research laboratory setting and expertise in process research and process development

Experience with the tools to develop, optimize, characterize, and scale up process steps

  

Other Job Details Must Have Work Authorization in US

Eligible for Relocation Assistance

Work Location Assignment: On Premise

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

2. Postdoctoral Fellow Computational Chemistry

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locations United States - Massachusetts - Cambridge

time type Full time

job requisition id4883074

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

ROLE SUMMARY

Pfizer Machine Learning Computational Sciences (MLCS) group is seeking a postdoc to conduct research aimed at developing state-of-the-art computational methods for small molecule crystal structure prediction. This is an exciting opportunity to perform fundamental research in a pharma setting on a topic that has important practical applications for small molecule pharmaceutical development. The successful applicant in this role will utilize First-principles approaches combined with machine learning and available small molecule crystal structure databases to develop methods that can rapidly and accurately predict crystal structures of small molecule APIs and intermediates. We are seeking a recent PhD with in-depth understanding of computational chemistry techniques as well as expertise in machine learning and scientific programming. The successful candidate will join a growing group of computational scientists and machine learning researchers who are passionate about developing novel computational methods and ML models to address challenging problems from early discovery to late-stage development and across established and emerging therapeutic modalities.

ROLE RESPONSIBILITIES

Conduct research with minimal supervision, with the aim of developing accurate and computationally efficient ML methods for small molecule crystal structure prediction.

Proactively engage key stakeholders at Pfizer for their input and feedback.

Identify opportunities for experimental validation and creative applications of the methods to portfolio projects.

Develop robust automated computational workflows, enabling methods to be run without significant manual input.

Publish research in high-impact journals.

Present at internal and external conferences.

QUALIFICATIONS

Basic Qualifications

Ph.D. in computational chemistry, physics, chemical engineering, computer science, or related discipline.

Strong track record of scientific excellence as evidenced by first-author publications in high-impact journals.

In-depth understanding of computational chemistry techniques, tools (e. g. electronic structure calculations and molecular mechanics), and common software packages.

Proficiency in Python; experience with scientific programming and algorithm design.

Experience with applying machine learning, in particular modern deep learning approaches, to solve relevant scientific problems.

Experience with Unix/Linux and HPC environments.

Excellent communication and interpersonal skills.

Preferred Qualifications

Strong background in Solid State Chemistry.

Experience with plane-wave DFT calculations and related QM packages such as VASP, Quantum Espresso etc.

Familiarity with Cambridge Crystal Structure Database and related CCDC tools for small molecule crystal structures analysis.

OTHER JOB DETAILS

Must Have Work Authorization in US

Eligible for Relocation Assistance

Work Location Assignment: On Premise

Relocation assistance may be available based on business needs and/or eligibility.

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

3. Postdoctoral Fellow, RNA Accelerator Inflammation and Immunology

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locations United States - Massachusetts - Cambridge

time type Full time

job requisition id4881227

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

ROLE SUMMARY

We have an exciting opportunity to join Pfizer’s Inflammation and Immunology Research Unit located in the heart of Cambridge’s biomedical research hub as a postdoctoral fellow. The position is with the Leukocyte Tissue Interface Group whose mission is to share immunology expertise across Pfizer’s various research units. The postdoctoral fellow will embark on a research project exploring novel engineering efforts to reprogram leukocytes using lipid-nanoparticle technologies, work collaboratively with diverse research teams within Pfizer, and publish their work in high-impact journals. This position presents a unique opportunity for well-trained immunologists and/or bioengineers who are also interested and passionate about receiving training in drug development. Your scientific research will give you the opportunity to immerse yourself in a dynamic pharmaceutical industry environment, to work with, learn from, and to influence fellow scientists. The postdoc will gain experience in disease-relevant immunology, cutting-edge RNA sequencing-based cell profiling and in vivo modeling. The ideal candidate should have solid training in immunology and good understanding of RNA sequencing techniques and mRNA engineering. You will be expected to deliver the results of your novel research internally via various working groups, via external conferences and through publications in quality scientific journals.

ROLE RESPONSIBILITIES

Demonstrate deep scientific and technical expertise harnessed to advance our understanding of LNP targeting, produce high-impact publications, present at conferences, and ultimately contribute to the delivery of novel, life-changing therapies for patients.

Contribute intellectually and at the bench to the project conception, design and execution.

Generate, organize, analyze, interpret data and communicate back to mentor. Identify areas where key knowledge is lacking. Proactively seek new scientific leads via systems immunology, literature, conferences, and key opinion leaders with the goal of refining scientific hypothesis and expediting experimental plans.

Be a proactive problem solver. Identifying roadblocks and propose innovative ways to provide solutions.

Effectively communicate results at internal and external events and proactively contribute to the continued scientific growth at Pfizer.

Contribute to a culture that embraces scientific excellence, effectiveness, and teamwork.

Exercise and build basic team effectiveness skills {e.g., commitment, feedback, consensus management) within context of immediate work group.

Collaborate and develop deep partnerships with Pfizer’s Next-Generation Sequencing Technology Center.

Ensure all tasks and responsibilities are carried out according to scientific and ethical standards.

Present the research work at various internal and external meetings and publish in high-impact journals.

QUALIFICATIONS

Basic Qualifications

Recent Ph.D., M.D. or M.D./Ph.D. in bioengineering and/or immunology.

1-2 first-author publications (published or manuscripts submitted for publication) in high-quality specialty or general readership journals.

Experience in animal handling and tissue harvesting, dissociation and cell isolation.

In vitro culture of primary cells and cell lines.

Demonstrated experience in diverse molecular and biochemical laboratory techniques applied to cell characterization at molecular or genetic levels (immunofluorescence, flow cytometry, qPCR, RNA sequencing).

Demonstrated proficiency in basic cell and molecular biology techniques including some of the following: Flow cytometry, ELISA/MSD, RNA/protein isolation from cells & tissues, qRT-PCR, Western blot.

Basic understanding of statistics and computational biology.

Well organized, self-motivated, team oriented, ability to multitask with attention to detail.

Preferred Qualifications:

Experience isolating and culturing primary human immune cells in vitro.

Experience transfecting/transducing cells using non-viral/viral methodologies.

Experience with RNA-seq data analysis.

Proficient in computational analysis and coding pipelines (R Studio, Python, etc.).

Excellent written and oral communication skills.

Self-directed with ability to work independently.

OTHER JOB DETAILS

Must Have Work Authorization in US

Eligible for Relocation Assistance

Relocation assistance may be available based on business needs and/or eligibility.

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

4, Postdoctoral Fellow, RNA Accelerator Inflammation and Immunology

Apply

locations United States - Massachusetts - Cambridge

time type Full time

job requisition id4881227

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

ROLE SUMMARY

We have an exciting opportunity to join Pfizer’s Inflammation and Immunology Research Unit located in the heart of Cambridge’s biomedical research hub as a postdoctoral fellow. The position is with the Leukocyte Tissue Interface Group whose mission is to share immunology expertise across Pfizer’s various research units. The postdoctoral fellow will embark on a research project exploring novel engineering efforts to reprogram leukocytes using lipid-nanoparticle technologies, work collaboratively with diverse research teams within Pfizer, and publish their work in high-impact journals. This position presents a unique opportunity for well-trained immunologists and/or bioengineers who are also interested and passionate about receiving training in drug development. Your scientific research will give you the opportunity to immerse yourself in a dynamic pharmaceutical industry environment, to work with, learn from, and to influence fellow scientists. The postdoc will gain experience in disease-relevant immunology, cutting-edge RNA sequencing-based cell profiling and in vivo modeling. The ideal candidate should have solid training in immunology and good understanding of RNA sequencing techniques and mRNA engineering. You will be expected to deliver the results of your novel research internally via various working groups, via external conferences and through publications in quality scientific journals.

ROLE RESPONSIBILITIES

Demonstrate deep scientific and technical expertise harnessed to advance our understanding of LNP targeting, produce high-impact publications, present at conferences, and ultimately contribute to the delivery of novel, life-changing therapies for patients.

Contribute intellectually and at the bench to the project conception, design and execution.

Generate, organize, analyze, interpret data and communicate back to mentor. Identify areas where key knowledge is lacking. Proactively seek new scientific leads via systems immunology, literature, conferences, and key opinion leaders with the goal of refining scientific hypothesis and expediting experimental plans.

Be a proactive problem solver. Identifying roadblocks and propose innovative ways to provide solutions.

Effectively communicate results at internal and external events and proactively contribute to the continued scientific growth at Pfizer.

Contribute to a culture that embraces scientific excellence, effectiveness, and teamwork.

Exercise and build basic team effectiveness skills {e.g., commitment, feedback, consensus management) within context of immediate work group.

Collaborate and develop deep partnerships with Pfizer’s Next-Generation Sequencing Technology Center.

Ensure all tasks and responsibilities are carried out according to scientific and ethical standards.

Present the research work at various internal and external meetings and publish in high-impact journals.

QUALIFICATIONS

Basic Qualifications

Recent Ph.D., M.D. or M.D./Ph.D. in bioengineering and/or immunology.

1-2 first-author publications (published or manuscripts submitted for publication) in high-quality specialty or general readership journals.

Experience in animal handling and tissue harvesting, dissociation and cell isolation.

In vitro culture of primary cells and cell lines.

Demonstrated experience in diverse molecular and biochemical laboratory techniques applied to cell characterization at molecular or genetic levels (immunofluorescence, flow cytometry, qPCR, RNA sequencing).

Demonstrated proficiency in basic cell and molecular biology techniques including some of the following: Flow cytometry, ELISA/MSD, RNA/protein isolation from cells & tissues, qRT-PCR, Western blot.

Basic understanding of statistics and computational biology.

Well organized, self-motivated, team oriented, ability to multitask with attention to detail.

Preferred Qualifications:

Experience isolating and culturing primary human immune cells in vitro.

Experience transfecting/transducing cells using non-viral/viral methodologies.

Experience with RNA-seq data analysis.

Proficient in computational analysis and coding pipelines (R Studio, Python, etc.).

Excellent written and oral communication skills.

Self-directed with ability to work independently.

OTHER JOB DETAILS

Must Have Work Authorization in US

Eligible for Relocation Assistance

Relocation assistance may be available based on business needs and/or eligibility.

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development