1. Post-Doctoral Research Associate
Role Description
Department
Applications are invited for a post-doctoral researcher to join the group of Dr Cécile Crosnier on the mechanisms of host:parasite interactions during the host immune response to Schistosoma mansoni infections. The position is funded by an MRC Career Development award, initially for three years. You will work in the Department of Biology and the York Biomedical Research Institute (YBRI) at the University of York. You will have access to the outstanding Bioscience Technology Facility, which offers access to a wide range of state-of-the-art imaging, proteomics, genomics and bioinformatics services. The Department of Biology is one of the largest departments at the University of York and delivers world-class science. Your research will have a strong focus on mechanisms of immunomodulation in the context of neglected tropical diseases and aligns with the Immunology, Haematology and Infection research theme of YBRI.
Role
The laboratory is looking for a talented, enthusiastic and motivated post-doctoral research associate with a strong interest in host:parasite interactions and immunology. You will be expected to conduct individual and collaborative research projects both within the Department of Biology and with external collaborators using a range of biochemical, serological and cellular approaches to investigate mechanisms of host immune modulation during infection by the Schistosoma mansoni parasite.
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Skills, Experience & Qualification needed
- PhD in Biology, Microbiology, Biochemistry, Immunology or related areas, or equivalent experience
- Knowledge in parasitology, immunology and/or biochemistry to engage in high quality research
- Knowledge of a range of research techniques and methodologies including tissue culture, molecular biology, recombinant protein production and purification
- Experience in mammalian and/or insect cell culture and molecular biology; additional experience in flow cytometry and/or cellular immune assays is desirable
- Experience of carrying out both independent and collaborative research
- Attention to detail and commitment to high quality
Interview date: to be determined
For informal enquiries: please contact Cécile Crosnier (cecile.crosnier@york.ac.uk)
The University strives to be diverse and inclusive – a place where we can ALL be ourselves.
We particularly encourage applications from people who identify as Black, Asian or from a Minority Ethnic background, who are underrepresented at the University.
We offer family friendly, flexible working arrangements, with forums and inclusive facilities to support our staff. #EqualityatYork
2. Postdoctoral Research Associate in Network Stochastic Processes and Time Series
Role Description
Department
Applications are invited for several (5) Postdoctoral Research Associate positions in Network Data Science, Statistics and Probability to work on an EPSRC-funded programme on Network Stochastic Processes and Time Series (NeST).NeST brings together the Universities of Bath, Bristol, Imperial College London, the London School of Economics and Political Science, Oxford and York, with industrial and government partners BT, EDF, the GCHQ, the Office for National Statistics, Microsoft, Royal Mail, Securonix and FNA. Stochastic network data are of rapidly increasing ubiquity in many fields such as medicine, transportation, cybersecurity, the environment, finance, biology and economics, and NeST aims to achieve a step change in the modelling and prediction of evolving, inter-connected stochastic network processes.
As part of the NeST team, you will contribute to realising a substantial coordinated push to create, develop and apply innovative new models, computational techniques and underpinning theory, in response to real applied problems spurred by dynamic networks in many contexts.
For the role advertised at the University of York, initially you will be attached to two research projects and be line managed in the Department of Mathematics by Prof. Marina Knight. As part of the NeST team, you will have access to, and potential opportunities to work with a larger team consisting of academics (Ed Cohen, Nick Heard, Guy Nason, Matt Nunes, Gesine Reinert, Patrick Rubin-Delanchy, Almut Veraart and Qiwei Yao) collectively covering a wide range of research in NeST areas, and a growing cohort of postdoctoral and PhD student colleagues spread over the constituent universities.
Projects that are available for this round of positions are P2 Modelling and Forecasting Dynamic Networks via their Edges (Lead/Line Manager: Knight, Yao/Marina Knight. Location: York. Team partners Heard, Nason, Nunes); P4 Dynamic Graph Embeddings: Procedures and Inference (Lead/Line Manager: Heard, Rubin-Delanchy/Nick Heard. Location: Imperial, London. Team partners: Knight, Nunes, Yao); P5 Network Count Processes (Lead/Line Manager: Ed Cohen. Location: Imperial, London. Team partners: Heard, Knight, Nason, Nunes Veraart); P6 Novel Long-Memory Spectral Domain Modelling for Network Data (Lead/Line Manager: Knight, Nunes/Matt Nunes. Location: Bath. Team partners: Cohen, Nason, Veraart); P7 Network Time Series in Continuous Time: Modelling and Estimation (Lead/Line Manager: Almut Veraart. Location: Imperial, London. Team partners: Cohen, Knight, Nason, Nunes, Reinert). P8 Novel Network Time Series Models with Application to Advanced Modelling and Prediction of Government Flow Data Sets (Lead/Line Manager: Nason, Nunes/Matt Nunes. Location: Bath).
See Job Description for further details of these projects. The role responsibilities and requirements are listed in the Job Description.
While there is a clear expectation of collaboration for the Postdoctoral Research Associates across projects and universities, please do indicate clearly in your application cover letter the institutions for which you would like to be considered, including your preferred choice. The available institutions for this round are Bath, Imperial College London and York.
If you are interested in more than one project at more than one location, then please apply to every project/institution that you are interested in using the links found at
https://www.ma.imperial.ac.uk/~gnason/nest.html
Since each position will contribute to the global success of the NeST programme, we will share the applications across the hiring institutions.
Role
This role is primarily for Project P2 Modelling and Forecasting Dynamic Networks via their Edges (Lead/Line Manager: Knight, Yao/Marina Knight. Team partners Heard, Nason, Nunes). You will also be involved in Project P6 Novel Long-Memory Spectral Domain Modelling for Network Data (Lead/Line Manager: Knight, Nunes/Matt Nunes. Location: Bath. Team partners: Cohen, Nason, Veraart).
For informal enquiries for the role at York: please contact Prof. Marina Knight by email marina.knight@york.ac.uk
Further information
The position is full-time, initially for 24 months. The successful candidate is expected to take up the position as soon as possible, but ideally before October 2023 for the right candidate.
The salary is on the University of York Grade 6 for the Research Associate position. All applicants with a relevant background and research skills are eligible to apply.
Please apply by completing the online application associated to this advert.
Closing date: 7th May 2023
Provisional interview timeline: candidates will be invited to a face-to-face interview at their chosen institution(s) in the interval 29th May to 9th June 2023. Offers will be made only after interviews across all institutions have taken place.
The University strives to be diverse and inclusive – a place where we can ALL be ourselves.
We particularly encourage applications from people who identify as Black, Asian or from a Minority Ethnic background, who are underrepresented at the University.
We offer family friendly, flexible working arrangements, with forums and inclusive facilities to support our staff. #EqualityatYork
3.Postdoctoral Research Associate (Archaeology)
Role Description
Department
The Department of Archaeology at the University of York is ranked 20th in the world and 5th in the UK in the QS rankings. We are based in both the King’s Manor in the heart of the historic city of York and at Heslington West campus. Our vibrant community consists of over 90 staff and over 600 students, with growing international representation. We carry out international, impact-oriented and interdisciplinary teaching and research of the highest quality through our strong network of partnerships. The student experience is of paramount importance to the Department and we maintain a high level of student satisfaction. Equality, diversity and inclusion are at our core and we promote a collegial environment in which staff and students feel supported and valued.
Role
This fixed term, full time Postdoctoral Research Associate position is part of the Leverhulme Trust funded project “Cults of the Head? The Dean Hall Temple carvings in context” led by Professor Ian Armit. The project examines the corpus of Late Iron Age/Romano-British carved stone heads from Dean Hall Roman Temple. Gloucestershire. The project will apply digital 3D modelling to the analysis and presentation of these carvings as well as traditional archaeological approaches.
The successful candidate will have a strong track record in archaeological research, with a period specialisation in later prehistory or Roman archaeology, and experience of working with databases. Experience in the use of digital 3D modelling is desirable.
Skills, Experience & Qualification needed
First degree in archaeology or a cognate discipline
PhD in archaeology or equivalent experience
Knowledge in later prehistoric and/or Roman archaeology sufficient to engage in high quality research
Experience of working with databases
Research expertise in an area that will complement and enhance the department's research strategy and goals
Highly developed communication skills to engage effectively with a wide ranging audience, both orally and in writing, using a range of media
Ability to write up research work for publication in high profile journals and engage in conferences, seminars and public dissemination
Experience in digital 3D modelling is desirable
Location: University of York - King's Manor (with some remote working options available)
Interview date: 18 May (TBC)
For informal enquiries: please contact Professor Ian Armit on ian.armit@york.ac.uk
The University strives to be diverse and inclusive – a place where we can ALL be ourselves.
We particularly encourage applications from people who identify as Black, Asian or from a Minority Ethnic background, who are underrepresented at the University.
We offer family friendly, flexible working arrangements, with forums and inclusive facilities to support our staff. #EqualityatYork
4. Postdoctoral Research Associate
Role Description
Role
Applications are invited for a postdoctoral researcher for 36 months (potential extension up to 54 months) to characterise signalling pathways that regulate autophagy and lysosome exocytosis during the lifecycle differentiation and host adaptation of the African trypanosome T. brucei. The position is funded by a MRC Career Development Award to Dr. Mathieu Cayla who will manage the post.
The project aims to reveal how phosphorylation controls autophagy and to characterise the molecular crosstalk between autophagy, lysosome exocytosis and differentiation. This will require the use of a wide range of different techniques such as high−throughput live imaging, gene silencing screens, mass spectrometry and murine infection models. Results obtained will provide fundamental understanding of the molecular composition and regulation of autophagy-related pathways in T. brucei and their roles in differentiation during the parasite’s lifecycle.
The successful applicant will join a team of researchers in the York Biomedical Research Institute investigating cellular processes in parasites that cause African trypanosomiasis. You will bring expertise in standard molecular biology and imaging techniques and should have a PhD in Molecular Biology, Cell Biology or Microbiology. Additionally, it would be desirable that the PDRA has knowledge in handling pathogens of class 2, in protein kinases and prior experience in: proteomics data analysis; super resolution microscopy and/or live imaging; and CRISPR/Cas9 mediated precision editing.
Department
Our laboratories provide a supportive and collaborative environment in which the PDRA can expand their range and learn new techniques. The Department of Biology is renowned internationally for its research, including biomedical research within the York Biomedical Research Institute. We strive to provide a working environment which allows all staff and students to contribute fully, flourish, and excel.
Key responsibilities
To conduct high quality research into post-translational modification systems regulating autophagy-related pathways and cellular differentiation in trypanosome parasites. The post must cover the following responsibilities:
- Development of high−throughput live imaging system combined with gene silencing screen of protein kinases
- Autophagy-related proximity labelling, phospho-proteomic and mass spectrometry analysis
- Assays of protein interaction and enzyme activity using biophysical and biochemical approaches
- Generation of mutated cell lines by CRISPR/Cas9 mediated precision editing and phenotypic validation in vitro and in murine model
Skills, Experience & Qualification needed
- A PhD in Molecular Biology, Cell Biology, Microbiology or related area
- Knowledge of post-translational modification systems, and of a range of modern molecular biology and imaging techniques to engage in high quality research
- Skilled and experienced in gene editing is desirable
- Experience is desirable in cell culture, and in handling of class 2 pathogens
- Highly developed communication skills
- Ability to develop research objectives, experience of conducting individual and collaborative research
- Evidenced ability to write up research work for publication and to present at conferences
- Interest in molecular biology and parasitology
- Attention to detail, collaborative ethos with interest in and enthusiasm for co-supervising students
- Ability to plan and prioritise own work to meet deadlines, using initiative to plan research
- Positive attitude to colleagues and students and a willingness to work proactively
- Commitment to personal development and understanding of equality and diversity issues
Interview date: To be confirmed
For informal enquiries: please contact Dr. Mathieu Cayla on mathieu.cayla@york.ac.uk
The University strives to be diverse and inclusive – a place where we can ALL be ourselves.
We particularly encourage applications from people who identify as Black, Asian or from a Minority Ethnic background, who are underrepresented at the University.
We offer family friendly, flexible working arrangements, with forums and inclusive facilities to support our staff. #EqualityatYork
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