Cornell university postdoc positions

1) Postdoctoral Positions in the Schwer and Shuman Labs

Date Posted	Faculty Name	Department	Email	Position Title
12.05.2022	Beate Schwer, Ph.D.	Microbiology and Immunology	bschwer@med.cornell.edu	Postdoctoral Positions in the Schwer and Shuman Labs

Two postdoctoral positions are available to pursue studies of RNA 3’-processing and transcription termination and of phosphate homeostasis in fission yeast in the laboratories of Prof. Beate Schwer (Weill Cornell Medical College) and Prof. Stewart Shuman (Memorial Sloan Kettering Cancer Center).

Topics of acute interest include: (i) lncRNA-mediated transcriptional interference; (ii) metabolite control of RNA 3’-processing/termination by inositol pyrophosphates; (iii) transcription control of phosphate homeostasis; and (iv) cellular responses and adaptations of fission yeast to phosphate starvation.

Representative publications:

Shuman, S. (2020) Transcriptional interference at tandem lncRNA and protein-coding genes: an emerging theme in regulation of cellular nutrient homeostasis. Nucleic Acids Res. 48:8243-8254.

Sanchez, A.M., Garg, A., Shuman, S. and Schwer, B. (2019) Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3' processing and transcription termination. Nucleic Acids Res 47, 8452-8469.

Schwer B, Garg A, Jacewicz A and Shuman S. (2021) Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factors Seb1. Proc Natl Acad Sci USA118, e2108105118

Benjamin, B., Garg, A., Jork, N., Jessen, HJ., Schwer, B. and Shuman, S. (2022) Activities and structure-function analysis of fission yeast inositol pyrophosphate (IPP) kinase-pyrophosphatase Asp1 and its impact on regulation of pho1 gene expression. mBio13: e0103422.

Job Requirements

Our multi-modal approach to the topics mentioned above integrates fission yeast genetics, protein and RNA biochemistry, transcription profiling, and structural biology. Candidates for the positions will have a PhD and experience in one or more of these areas.

Interested candidates please forward CV and contact information for 2 referees to:

Dr. Beate Schwer, Weill Cornell Medical College: bschwer@med.cornell.edu

Dr. Stewart Shuman, Memorial Sloan Kettering Cancer Center:  shumans@mskcc.org

The salary range for the positions is: $58,500 – $66,538.

Weill Cornell Medicine provides the above salary range in compliance with the New York City law on Salary Transparency in Job Advertisements. The salary range listed is for full‐time employment not including bonuses, clinical incentive compensation, or benefits. Actual salaries depend on a variety of factors including but not limited to internal equity, specialty, training, and hospital/community needs. The above salary range for New York City based roles represents WCM’s good faith and reasonable estimate of possible compensation at the time of posting.

Contact

Beate Schwer, Ph.D.

Microbiology and Immunology

bschwer@med.cornell.edu

2) Postdoctoral Fellow Position Available in the Lab of Dr. Melody Zeng

Date Posted	Faculty Name	Department	Email	Position Title
11.30.2022	Melody Zeng, Ph.D.	Pediatrics	myz4001@med.cornell.edu	Postdoctoral Fellow Position Available in the Lab of Dr. Melody Zeng

The Zeng lab is seeking motivated and enthusiastic postdoctoral fellows to join our lab to lead projects to investigate gut microbiome-host interactions in the contexts of early immune system development or cancer progression and metastasis. The Zeng has developed innovative gnotobiotic mouse models and genetic knockout mice for studies of the development of the immune system and the crosstalk between immune cells and gut bacteria in infection and cancer. We are well equipped to integrate multi-disciplinary approaches to study the interactions between immune cells and gut commensal bacteria using mouse models of inflammation, infection or cancer, and gnotobiotic mouse models established by leveraging an existing human stool biobank in the Zeng lab.

Recent publications by the Zeng lab:

Sanidadet al. Maternal gut microbiome-induced IgG regulates neonatal gut microbiome and immunity. Science Immunology. 2022. PMID: 35687695

Brownet al. Gut microbiome regulates viral entry and immune and coagulation responses in SARS-CoV-2 infection. Gut Microbes. 2022. PMID:35915556

Jin et al. SARS CoV-2 detected in neonatal stool remote from maternal COVID-19 during pregnancy. Pediatric Research. 2022. PMID:35986143

Amir M and Zeng MY. Immune imprinting in utero. Science, 2021. PMID: 34446596

We are located within a vibrant research hub on the Upper East Side of Manhattan in New York City with access to the most cutting-edge technologies and many opportunities for collaboration with world-class researchers at Weill Cornell Medicine and neighboring Memorial Sloan Kettering Cancer Center, Rockefeller University, and the Hospital of Special Surgery. As members of outstanding and highly collaborative groups within the Drukier Institute for Children’s Health (https://drukierinstitute.weill.cornell.edu/) and the Tri-institutional Immunology and Microbial Pathogenesis Graduate Program (https://gradschool.weill.cornell.edu/programs/immunology-microbial-pathogenesis) at Weill Cornell Medicine, all members of the Zeng lab will have the opportunities to present research work at seminar series and participate in all activities organized by these groups.

For additional information about the Zeng lab, please visit the following:

Lab Website:https://zeng-lab.org/

Twitter:https://twitter.com/melodyzeng/

Instagram:https://www.instagram.com/zenglaboratory/

Job Requirements

Required Experience: Ph.D./M.D. with expertise in immunology, molecular biology, cancer biology, or microbiology. Experience in techniques including flow cytometry, imaging, molecular biology, bioinformatics, and mouse models of inflammation, infection and/or cancer are desirable.

To apply: We encourage and welcome interested and qualified candidates of all backgrounds, either U.S. citizens or international candidates, to apply. To do so, please email a one-page cover letter describing past research achievements and future research interests/goals, a CV, and three letters of recommendation to:

Melody Zeng, Ph.D.

Assistant Professor of Immunology in Pediatrics

myz4001@med.cornell.edu

Contact

Melody Zeng, Ph.D.

3) Postdoctoral Associate Position Available in the Siolas Lab

Date Posted	Faculty Name	Department	Email	Position Title
11.30.2022	Despina Siolas, M.D., Ph.D.	Medicine	Des2025@med.cornell.edu	Postdoctoral Associate Position Available in the Siolas Lab

The Siolas lab is seeking a Postdoctoral Associate to work within the Department of Medicine at Weill Cornell Medicine in New York City. The Siolas Laboratory conducts research on cancer genes that influence the immune microenvironment focusing on gastrointestinal mouse models of pancreatic cancer and colon cancer. The lab uses techniques in genetics and immunology to understand how tumors develop and become resistant to therapy using mouse models. Our research laboratory is a multi-level training group consisting of people with different backgrounds, training levels and skill sets.

We seek an outstanding individual with Ph.D. training in cancer biology, genetics or immunology to study the mechanistic basis of tumor immune evasion in gastro-intesinal cancer. Learn more about our research at: https://vivo.weill.cornell.edu/display/cwid-des2025

The fellow will join an expanding research group focused on understanding the relationship between cancer genes and the immune microenvironment. The fellow will lead laboratory-based studies to identify immune phenotypes associated with different tumor genotypes and sites of origins with opportunities to expand into additional cancer sites. As an active member of an interdisciplinary team, the fellow will build relationships with a range of scientific colleagues, publish peer-reviewed work, present at national conferences, and gain experience in grant writing.

Job Requirements

PhD. and/or M.D./Ph.D. degree in genetics, cell biology, immunology or molecular biology.The fellow Effective communication skills, self-motivated, and a strong work ethic. Ability to work both independently and in a collaborative group environment Peer-reviewed publications in molecular genetics, gene regulation, or related fields. Strong interest in understanding the biological/mechanistic basis of pancreatic or colon cancer. Established skills in standard laboratory techniques, e.g., cell culture, molecular cloning, mouse handling, transfections, CRISPR, qPCR. Self-motivated, resourceful, enthusiastic.

Contact

Despina Siolas, M.D., Ph.D.

Medicine

Des2025@med.cornell.edu

Pediatrics

myz4001@med.cornell.edu

4) Postdoctoral Fellow/Research Associate-Laboratory of Molecular and Translational Vascular Research

Date Posted	Faculty Name	Department	Email	Position Title
11.30.2022	Teresa Sanchez, Ph.D.	Pathology and Laboratory Medicine/Neuroscience	tes2015@med.cornell.edu	Postdoctoral Fellow/Research Associate-Laboratory of Molecular and Translational Vascular Research

The Laboratory of Molecular and Translational Vascular Research in the Dept. Pathology and the Brain and Mind Research Institute, Weill Cornell Medicine, is seeking candidates for the position of Postdoctoral Fellow/Research Associate. A NIH-funded position is immediately available to investigate the molecular mechanisms governing endothelial dysfunction. The candidate must have experience in molecular, cell biology and in vivo mouse models (e.g. stroke, sepsis). Our research team studies the molecular and cellular mechanisms governing endothelial dysfunction with a special emphasis on exploring the therapeutic potential of the endothelium to prevent tissue injury and promote repair in the context of cerebrovascular diseases and systemic inflammatory response syndrome/sepsis. We routinely use molecular and cellular biology approaches, as well as mouse models of vascular injury. More information can be found at https://pathology.weill.cornell.edu/research/research-labs/laboratory-mo... and https://brainandmind.weill.cornell.edu. The candidate will join a dynamic, highly collaborative, and multidisciplinary research team and will have the opportunity to conduct both basic and translational research, to acquire experience in drug development and to receive strong mentorship for a successful career path in academia or industry. 

Job Requirements

Applicants must have recently obtained a PhD in Molecular, Cell Biology or Neuroscience, and have a strong track record of publications, teamwork, and collegiality.

Individuals who are interested in this position please send 1) your Curriculum Vitae 2) statement of research interests and 3) the names of 3 references to Dr. Teresa Sanchez at tes2015@med.cornell.edu.

Salary Range is: $58,500 – $65,320. Weill Cornell Medicine provides the above salary range in compliance with the New York City law on Salary Transparency in Job Advertisements. The salary range listed is for full-time employment not including bonuses, clinical incentive compensation, or benefits. Actual salaries depend on a variety of factors.

Contact

Teresa Sanchez, Ph.D.

Pathology and Laboratory Medicine/Neuroscience

tes2015@med.cornell.edu

5) Postdoctoral Position Available in the Lab of Dr. Heidi Stuhlmann

Date Posted	Faculty Name	Department	Email	Position Title
11.30.2022	Heidi Stuhlmann, Ph.D.	Cell and Developmental Biology	hes2011@med.cornell.edu	Postdoctoral Position Available in the Lab of Dr. Heidi Stuhlmann

A postdoctoral position is available in the laboratory of Dr. Heidi Stuhlmann in the Department of Cell and Developmental Biology at Weill Cornell Medicine (WCM). Weill Cornell is part of a Tri-Institutional campus in New York City which provides easy interactions with colleagues at Sloan Kettering Institute and Rockefeller University. The major focus of the Stuhlmann lab is to study the molecular and mechanistic links between defects in placental development and neurodevelopmental and metabolic disorders. Another focus is to understand the impact of SARS-CoV-2 infection on the human placenta. Representative publications from the lab include:

Lacko, L.A. et al. (2017). Altered feto-placental vascularization, placental malperfusion, and fetal growth restriction in mice with Egfl7 loss-of-function. Development 144(13): 2469-2479. [PMCID: PMC5536866]; Sharma, A. et al. (2019). miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta. Dev. Biol. 449:21-34. [PMCID: PMC6451886 DOI: 10.1016/j.ydbio.2019.01.019];

Argueta, L.B. et al. (2022). Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy. iScience 25 (5): 104223. [PMCID: PMC8996470 DOI: 10.1016/j.isci.2022.104223].

Job Requirements

A recent PhD in biomedical science-related fields and proficiency in English are required. Proficiency in mouse models, dissection of mouse embryos, in vitro primary cell cultures, molecular and cellular techniques including molecular cloning, PCR, western blotting and immunohistochemistry, and skills in data analysis, statistical methods and writing are preferred. The candidate is expected to be highly motivated and to interact with scientists and trainees in the Stuhlmann lab and collaborators within WCM.

If interested, submit a CV, a brief cover letter indicating your research experience, career goals and the names and contact information of 2 referees to Dr. Heidi Stuhlmann (hes2011@med.cornell.edu)

Salary Range for this position is: $58,500 - $66,538. Weill Cornell Medicine provides the above salary range in compliance with the New York City law on Salary Transparency in Job Advertisements. The salary range listed is for full‐time employment not including benefits, bonuses, or clinical incentive compensation where applicable. Actual salaries depend on a variety of factors including but not limited to internal equity, specialty, training, and hospital/community needs. The above salary range for New York City based roles represents WCM’s good faith and reasonable estimate of possible compensation at the time of posting. Weill Cornell Medicine is an Equal Employment Opportunity Employer. Weill Cornell Medicine provides equal employment opportunities to all qualified applicants without regard to race, sex, sexual orientation, gender identity, national origin, color, age, religion, protected veteran or disability status, or genetic information.

Contact

Heidi Stuhlmann, Ph.D.

Cell and Developmental Biology

hes2011@med.cornell.edu

6) Joint Postdoctoral Position in the Kleaveland and Lai Labs

Date Posted	Faculty Name	Department	Email	Position Title
11.30.2022	Benjamin Kleaveland, M.D., Ph.D.	Pathology and Lab Medicine	bek9059@med.cornell.edu	Joint Postdoctoral Position in the Kleaveland and Lai Labs

The Lai and Kleaveland labs at Sloan Kettering Institute and Weill-Cornell Medicine, respectively, are excited to recruit for a joint position to investigate the roles of RNAi / Argonaute-2 catalysis in mammalian development and tissue homeostasis. While RNAi is well-appreciated to suppress selfish elements and is also a powerful experimental tool, a fundamental question remains largely unsolved: why do mammals preserve enzymatic activity of Argonaute-2? If you are curious and passionate about RNA and seek to integrate molecular regulatory mechanisms with in vivo phenotypes, we would love to work with you to discover the endogenous substrates of the RNAi pathway that are required for mammalian biology. The Lai/Kleaveland labs have a rich supply of mouse and human ESC knockin/knockout models, along with extensive unpublished data, to drive this effort forward. We offer a unique opportunity to train jointly in creative and collaborative environments, with access to a broad range of techniques used by the Lai/Kleaveland labs to study a range of RNA mechanisms and their biological impacts. Please visit the lab websites (https://www.mskcc.org/research/ski/labs/eric-lai; www.kleavelandlab.org) for more information.

Relevant papers on Ago2 catalysis in mammals:

Jee D, Yang JS, Park SM, Farmer DT, Wen J, Chou T, Chow A, McManus MT, Kharas MG, Lai EC (2018). Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals. Molecular Cell 69: 265-278.

Kleaveland B, Shi CY, Stefano J, Bartel DP (2018). A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain. Cell 174: 350-362

Job Requirements

The project will involve molecular techniques, cell biology, bioinformatics and/or biochemistry, and the ideal candidate will be experienced with several of these approaches. Expertise in molecular neuroscience, stem cells, or mouse models is valued though not required. All relevant techniques can be learned from our groups and our strong network of Tri-I collaborators. We value kindness, grit, and diversity—women and minorities are specifically encouraged to apply. 

Contact: Interested applicants should send their CV, contact information for 3 references, and a cover letter that includes research interests and career goals to:

Ben Kleaveland, MD/PhD Weill Cornell Medicine bek9059@med.cornell.edu

Eric Lai, PhD Memorial Sloan Kettering Cancer Center laie@mskcc.org

Competitive salary and benefits will be provided. The salary range* is: $58,500 - $65,320.

Weill Cornell Medicine provides the above salary range in compliance with the New York City law on Salary Transparency in Job Advertisements. The salary range listed is for full‐time employment not including bonuses, clinical incentive compensation, or benefits. Actual salaries depend on a variety of factors including but not limited to internal equity, specialty, training, and hospital/community needs. The above salary range for New York City based roles represents WCM’s good faith and reasonable estimate of possible compensation at the time of posting.

Contact

Benjamin Kleaveland, M.D., Ph.D.

Pathology and Lab Medicine

bek9059@med.cornell.edu

For details please visit the official site