Post-doctoral Positions at University of Montreal

POSTDOCTORAL POSITION #1

ORGANISATION/COMPANY       University of Montreal

RESEARCH FIELD                   Biological sciences › Biological engineering Chemistry › Biochemistry

RESEARCHER PROFILE                First Stage Researcher (R1)

                                                           Established Researcher (R3)

                                                           Recognized Researcher (R2)

APPLICATION DEADLINE            31/05/2022 18:00 - America/New York

LOCATION                                       Canada › Montréal

TYPE OF CONTRACT                    Temporary

JOB STATUS                                     Full-time

HOURS PER WEEK                          35

OFFER STARTING DATE                 01/09/2022

Description

The Montreal Laboratory for Chemical Glycomics is inviting applications for a project on glycol-engineering of therapeutic antibodies. This one-year renewable position is available immediately within the Cecioni research group at Université de Montréal but the project is built around a strong collaborative team including Pr. Pelletier (UdeM), Pr. Rullo (McMaster) and Pr. Kwan (Concordia).

Area of research:

The advent of biopharmaceuticals is revolutionizing health care, opening up entirely new avenues against diseases that are difficult to treat using traditional drugs. In a rapidly changing industry, more than 50% of Top 10 drugs now consist of monoclonal therapeutic antibodies. To be efficient, they also require post-translational glycosylation, which means the antibody is linked to a complex structure of various sugars (i.e. glycans). Consequently, most therapeutic mAbs are still not single homogenous proteins. This glycosylation of key conserved residues remains difficult to control, thereby imposing a significant burden on the development and use of therapeutic antibodies.

Project:

In that context, we will develop better strategies for controlling the structure and homogeneity of mAbs glycans (sugars). In particular, we will leverage chemo-enzymatic technologies in continuous flow in order to scale up engineering of glycosylation, potentially making a high impact on biomedical research and biotech industry.

We propose to address current limitations using innovative approaches in bioengineering, continuous flow biocatalysis and synthetic biology.

Candidates:

We are currently inviting applications from highly motivated researchers with a broad interest and expertise in chemical biology, biocatalysis and bioengineering toward improving human health. Selected scientists will demonstrate great problem-solving skills, a deep interest for innovative therapeutic approaches and a strong theoretical and experimental background in bio-organic chemistry, in biochemistry and/or bioanalytical sciences. Specifically, we are looking for scientists that have demonstrated exceptional research abilities and leadership. Candidates should be proficient at biochemistry techniques such as protein purification, enzymatic activity measurements, bioanalytical methods (FPLC, HPLC, LC-MS/MS), flow biocatalysis as well as complex data set analysis.

At Université de Montréal, postdoctoral researchers are supported in accordance with UdeM’s postdoc collective agreement (salary, paid holidays, healthcare benefits). More information is available on:

https://esp.umontreal.ca/english/postdoctoral-fellow/publications/

For more information on this project or on glycoscience, please contact Prof. Cecioni and visit the group website cecionilab.com.

How to apply:

Applicants should send their application file to Prof. Cecioni (samy.cecioni@umontreal.ca). Application should include a resume, a cover letter highlighting significant accomplishments and contact details for at least 2 potential references. Please Visit the Official site

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POSTDOCTORAL POSITION #2

Job Title                      Post-doctoral fellow

Division                      Molecular Pharmacology

Supervisor                   Prof Michel Bouvier

Application Deadline  May 13, 2022.

Employment Title: Post-doctoral fellow

Research Unit: Laboratory of Prof Michel Bouvier (Molecular Pharmacology), Institute for Research in Immunology and Cancer (IRIC), University of Montreal, in collaboration with My Intelligent Machines (MiMS)

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 Description

We are looing for a postdoctoral fellow in the field of application of artificial intelligence to the analysis of cell signaling data in the context of anti-cancer drug action. The selected candidate will join a collaborative project between the laboratory of Prof Michel Bouvier of the Institute for Research in Immunology and Cancer (IRIC) (https://www.iric.ca/fr) from the University of Montreal and the artificial intelligence company MiMS (https://www.mims.ai/). The project is part of the large-scale research program, Acuité (https://www.youtube.com/watch?v=ac5B7dRA33o), supported by the Fonds d’Accélération des Collaborations en Santé (FACS). The candidate will share its time between Prof Bouvier’s laboratory and those of MiMS.

The project aims to integrate cell signaling data into algorithms for predicting the activity of anti-cancer drugs with a view to a better understanding of the mechanisms of action of these drugs and a better identification of patients who could benefit from these treatments. The prediction algorithms were generated by MiMS and the involvement in therapeutic responses will be assessed by measuring their activity and dynamics in real time in live cells classified as responder vs non-responder based on existing data.

Responsibilities of the Candidate

Use the MIMs algorithmic platform (paid from dedicated Acuity funds by the Bouvier laboratory);

Use different BRET sensors to detect signaling signatures;

Develop a new panel of biosensors of the wnt/Frizzled/beta-catenin axis;

Establish appropriate targets and drugs to be tested and perform BRET experiments to validate predictions from the MiMs algorithmic platform;

Test the set of biosensors in several cell lines, using transient transfection and viral transduction. These preliminary tests and optimizations will be useful for the experiments to be developed in the next stages of the project;

Assure the contact with the industrial partner of the project and coordinate the different aspects of the collaboration;

In collaboration with the principal investigators, interpret the results and plan the next steps of the project;

In collaboration with the principal researcher, conceptualize and produce the various documents related to the project (eg oral presentation, written reports, scientific manuscripts and grant applications, if applicable);

Prepare and present scientific results from research at national and international scientific conferences and symposia (posters and/or oral presentation) as well as to local and international collaborators.

Job Requirements (Education and experience)

In accordance with the policy on the status of postdoctoral fellows of the University of Montreal, hold, for less than 3 years, a research doctorate in an appropriate field of specialization (biochemistry, cell biology, pharmacology, artificial intelligence , etc…);

Have practical knowledge of big data analysis and programming;

Previous experience in mammalian cell culture and in vitro experiments;

Good knowledge of the biology of G protein-coupled receptors (GPCRs);

Ability to develop new experimental protocols;

Knowledge of medicinal chemistry would be an asset.

Job parameters

2-year contract with possibility of extension;

Start of contract: As soon as possible from;

Salary: To be determined based on the profile of the candidate and the minimum and maximum set out by the collective agreement. 

How to Apply

Submit your application (cover letter, CV and the names of two references that we could contact) to the attention of Roseline Nerette Dehaut (roseline.nerette.dehaut@umontreal.ca).

Also Visit the official site

POSTDOCTORAL POSITION #3

Research Project Title

Defining implication of Malassezia fungi in autoimmune diseases and cancers

Description

We are looking for a postdoctoral fellow to join the Human Immunology Laboratory on a full-time basis, within the Cancer Axis of the Centre de recherche du Centre hospitalier de l'Université de Montréal (CHUM). The successful candidate will support the realization of various projects related to the involvement of Malassezia in human health, and in autoimmune diseases and cancers. Malassezia species are amongst the most abundant fungi in humans, found mostly in mucosal surfaces and on the skin. However, Malassezia can cause damage when present in tissue, in particular in Crohn’s disease and pancreatic cancer, but knowledge of Malassezia’s involvement in diseases of internal organs remains fragmented and incomplete. The project will involve determining if Malassezia are present at the site of multiple autoimmune diseases and cancers. Several methods will be used including staining using antibodies and other molecular tools. Also, immune response to Malassezia will be evaluated in these diseases at the humoral (antibody) and cellular levels, using state-of-the-art approaches.

Requirements

- Completed doctoral studies in the biological sciences, health sciences or a relevant field of study

- Excellent record of scientific publication and communication

- Interest in pursuing research in human immunology

- Strong interpersonal and communication skills

- Organizational skills and effective time management

- Experience working as part of an interdisciplinary team.

Application Submission

If you are interested in this position, please send your application to Dr. Réjean Lapointe, PhD, Head of the CRCHUM Cancer Research Axis by May 2nd, 2022. Please specify "Postdoctoral Fellow" in the subject line of your message and attach:

- A cover letter

- Your CV

- Two letters of recommendation.

Benefits

A competitive salary and full benefits financed by a joint Malassezia Foundation/MITACS postdoctoral research funding.

Selection process

The candidate will be selected using the regular selection process employed at CRCHUM. Only successful candidates will be contacted for an interview.

CRCHUM and Université de Montréal are strongly committed to fostering diversity and inclusion. Through their Equal Access Employment Program, CRCHUM and UdeM invite applications from women, Aboriginal people, visible and ethnic minorities, as well as persons with disabilities. They will confidentially adapt their recruitment mechanisms to the specific needs of people with disabilities who request it. They also welcome applications from candidates of all orientations and sexual identities. All qualified applicants are encouraged to apply; however, in accordance with Canadian immigration requirements, priority will be given to Canadians and permanent residents.

Research Center of the Centre hospitalier de l’Université de Montréal (CRCHUM)

CHUM and its research center (CRCHUM) is one of the largest hospital-based research centres in North America. The CHUM Research Centre is a place of excellence where knowledge, expertise and innovation coexist, bringing tangible benefits to patients. More than 1800 employees including over 500 researchers and 400 students integrate the entire research continuum, including basic, clinical and population health research

Université de Montréal

The Université de Montréal is one of the leading research universities in Canada. Together, with its two affiliated schools, HEC Montréal and École Polytechnique, it constitutes one of the largest centres of higher education in North America.

Job Types: Full-time, Fixed term contract

Contract length: 24 months

Salary: $45,000.00-$70,413.00 per year

Schedule:

Monday to Friday

Weekend availability

COVID-19 considerations:

All employees must strictly comply to the CHUM regulations.

Education:

Doctoral Degree (preferred)

Application deadline: 2022-05-02

Please visit the site for more details